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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SPRY2 All Species: 26.06
Human Site: T305 Identified Species: 57.33
UniProt: O43597 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43597 NP_005833.1 315 34688 T305 T V C C K V P T V P P R N F E
Chimpanzee Pan troglodytes XP_517428 319 35122 S309 T V Y C K L E S C P S R G Q G
Rhesus Macaque Macaca mulatta XP_001090386 613 65978 T603 T V C C K V P T V P P R N F E
Dog Lupus familis XP_542623 315 34699 T305 T V C C K V P T V P P R N F E
Cat Felis silvestris
Mouse Mus musculus Q9QXV8 315 34605 T305 T V C C K V P T V P P R N F E
Rat Rattus norvegicus Q3C2P8 410 46787 R330 D A V R T C I R R V S C M W C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510585 619 67001 S609 T V C C K V P S V P P R N F E
Chicken Gallus gallus Q9PTL2 313 34398 S303 T V C C K V P S V P P R N F E
Frog Xenopus laevis NP_001082238 314 35083 H304 T V C L K V P H L Q P R N L E
Zebra Danio Brachydanio rerio Q6NYK3 413 46811 T330 D A P D P I R T C I H R V S F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O44783 589 62370 G505 G C R C Q G I G G G G A G S G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 52.3 48.6 97.1 N.A. 96.5 20.2 N.A. 44.4 85.4 74.2 21 N.A. 23 N.A. N.A. N.A.
Protein Similarity: 100 67.7 50.2 97.4 N.A. 97.4 33.9 N.A. 46.8 90.7 81.5 32.2 N.A. 34.1 N.A. N.A. N.A.
P-Site Identity: 100 40 100 100 N.A. 100 0 N.A. 93.3 93.3 66.6 13.3 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 53.3 100 100 N.A. 100 6.6 N.A. 100 100 73.3 20 N.A. 13.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 19 0 0 0 0 0 0 0 0 0 10 0 0 0 % A
% Cys: 0 10 64 73 0 10 0 0 19 0 0 10 0 0 10 % C
% Asp: 19 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 64 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 55 10 % F
% Gly: 10 0 0 0 0 10 0 10 10 10 10 0 19 0 19 % G
% His: 0 0 0 0 0 0 0 10 0 0 10 0 0 0 0 % H
% Ile: 0 0 0 0 0 10 19 0 0 10 0 0 0 0 0 % I
% Lys: 0 0 0 0 73 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 10 0 10 0 0 10 0 0 0 0 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 64 0 0 % N
% Pro: 0 0 10 0 10 0 64 0 0 64 64 0 0 0 0 % P
% Gln: 0 0 0 0 10 0 0 0 0 10 0 0 0 10 0 % Q
% Arg: 0 0 10 10 0 0 10 10 10 0 0 82 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 28 0 0 19 0 0 19 0 % S
% Thr: 73 0 0 0 10 0 0 46 0 0 0 0 0 0 0 % T
% Val: 0 73 10 0 0 64 0 0 55 10 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _